Acetaldehyde Dehydrogenases in Liver Zonation and Liver Cancer

The liver maintains important homeostatic functions such as metabolism and detoxification. Failure to remove toxic intermediates can cause hepatic damage, fibrosis, even cancer development. This review focuses on acetaldehyde dehydrogenases (ALDHs), a group of key enzymes within the ALDH superfamily with ability convert highly reactive aldehyde substrates corresponding carboxylic acids in NAD(P)-dependent manners. These participate diverse array biological processes detoxification, biosynthesis, antioxidant, regulatory functions. dysfunction disrupt homeostasis, leading buildup, tissue cancer. Here, we examine expression patterns ALDHs adult normal human livers two types cancers—hepatocellular carcinoma cholangiocarcinoma. We also investigated their distributions related zonation. observations provide deep insights into previously unrecognized spatial temporal regulation